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USC-OGP 2-DE database
Two-dimensional polyacrylamide gel electrophoresis database
USC-OGP 2-DE database
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Searching in 'USC-OGP 2-DE database' for entry
matching:
IF4E_HUMAN
USC-OGP 2-DE database
:
IF4E_HUMAN
IF4E_HUMAN
General information about the entry
View entry in simple text format
Entry name
IF4E_HUMAN
Primary accession number
P06730
integrated into USC-OGP 2-DE database on
January 17, 2017 (release 1)
2D Annotations were last modified on
January 17, 2017 (version 1)
General Annotations were last modified on
April 5, 2017 (version 2)
Name and origin of the protein
Description
RecName: Full=Eukaryotic translation initiation factor 4E; Short=eIF-4E; Short=eIF4E; AltName: Full=eIF-4F 25 kDa subunit; AltName: Full=mRNA cap-binding protein;.
Gene name
Name=EIF4E
Synonyms=EIF4EL1, EIF4F
Annotated species
Homo sapiens (Human) [TaxID:
9606
]
Taxonomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]
2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein
PLATELET_5-6
{PLATELET 5-6}
Homo sapiens (Human)
map experimental info
PLATELET_5-6
MAP LOCATIONS:
SPOT OGP-0806
:
pI=5.31; Mw=26139
UVEAL_MELANOMA_3-10
{UVEAL MELANOMA 3-10}
Homo sapiens (Human)
map experimental info
UVEAL_MELANOMA_3-10
MAP LOCATIONS:
SPOT OGP-1273
:
pI=5.83; Mw=27756
Cross-references
UniProtKB/Swiss-Prot
P06730; IF4E_HUMAN.
2D PAGE maps for identified proteins
How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1
: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2
: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
External data extracted from
UniProtKB/Swiss-Prot
Extracted from
UniProtKB/Swiss-Prot
, release:
0.0
Entry name
IF4E_HUMAN
Primary accession number
P06730
Secondary accession number(s)
B7Z6V1 D6RCQ6 Q96E95
Sequence was last modified on
February 1, 1996 (version 2)
Annotations were last modified on
March 15, 2017 (version 195)
Name and origin of the protein
Description
RecName: Full=Eukaryotic translation initiation factor 4E; Short=eIF-4E; Short=eIF4E; AltName: Full=eIF-4F 25 kDa subunit; AltName: Full=mRNA cap-binding protein;
Gene name
Name=EIF4E
Synonyms=EIF4EL1, EIF4F
Encoded on
Name=EIF4E; Synonyms=EIF4EL1, EIF4F
Keywords
3D-structure
;
Acetylation
;
Alternative splicing
;
Autism
;
Autism spectrum disorder
;
Chromosomal rearrangement
;
Complete proteome
;
Cytoplasm
;
Direct protein sequencing
;
Host-virus interaction
;
Initiation factor
;
Phosphoprotein
;
Protein biosynthesis
;
Reference proteome
;
RNA-binding
;
Translation regulation
.
Copyright
Copyrighted by the UniProt Consortium, see
http://www.uniprot.org/help/license
. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL
M15353; AAC13647.1
; -; mRNA
EMBL
AK300982; BAH13387.1
; -; mRNA
EMBL
AC019131; -
; NOT_ANNOTATED_CDS; Genomic_DNA
EMBL
AC093836; -
; NOT_ANNOTATED_CDS; Genomic_DNA
EMBL
BC012611; AAH12611.1
; -; mRNA
EMBL
BC035166; AAH35166.1
; -; mRNA
EMBL
BC043226; AAH43226.1
; -; mRNA
EMBL
BM849222; -
; NOT_ANNOTATED_CDS; mRNA
CCDS
CCDS34031.1; -. [P06730-1]
; .
CCDS
CCDS47109.1; -. [P06730-3]
; .
CCDS
CCDS54779.1; -. [P06730-2]
; .
PIR
A26411; A26411
; .
RefSeq
NP_001124150.1; NM_001130678.2. [P06730-3]
; .
RefSeq
NP_001124151.1; NM_001130679.2. [P06730-2]
; .
RefSeq
NP_001317946.1; NM_001331017.1
; .
RefSeq
NP_001959.1; NM_001968.4. [P06730-1]
; .
UniGene
Hs.13211; -
; .
UniGene
Hs.249718; -
; .
PDB
1IPB; X-ray
; 2.00 A; A=1-217
PDB
1IPC; X-ray
; 2.00 A; A=1-217
PDB
1WKW; X-ray
; 2.10 A; A=27-217
PDB
2GPQ; NMR
; -; A=1-217
PDB
2V8W; X-ray
; 2.30 A; A/E=1-217
PDB
2V8X; X-ray
; 2.30 A; A/E=1-217
PDB
2V8Y; X-ray
; 2.10 A; A/E=1-217
PDB
2W97; X-ray
; 2.29 A; A/B=1-217
PDB
3AM7; X-ray
; 2.20 A; A=27-217
PDB
3TF2; X-ray
; 2.10 A; A/B/C/D=1-217
PDB
3U7X; X-ray
; 2.10 A; A/B=1-217
PDB
4AZA; X-ray
; 2.16 A; A/C=1-217
PDB
4BEA; X-ray
; 2.57 A; A=1-217
PDB
4DT6; X-ray
; 2.60 A; A=1-217
PDB
4DUM; X-ray
; 2.95 A; A=1-217
PDB
4TPW; X-ray
; 1.50 A; A/B=28-217
PDB
4TQB; X-ray
; 1.59 A; A/B=28-217
PDB
4TQC; X-ray
; 1.80 A; A/B=28-217
PDB
4UED; X-ray
; 1.75 A; A=36-217
PDB
5EHC; X-ray
; 2.40 A; A=1-217
PDB
5EI3; X-ray
; 1.71 A; A=1-217
PDB
5EIR; X-ray
; 2.69 A; A=1-217
PDB
5EKV; X-ray
; 3.61 A; A/C=1-217
PDB
5GW6; X-ray
; 1.97 A; A=23-217
PDB
5T46; X-ray
; 1.53 A; A/C=1-217
PDBsum
1IPB; -
; .
PDBsum
1IPC; -
; .
PDBsum
1WKW; -
; .
PDBsum
2GPQ; -
; .
PDBsum
2V8W; -
; .
PDBsum
2V8X; -
; .
PDBsum
2V8Y; -
; .
PDBsum
2W97; -
; .
PDBsum
3AM7; -
; .
PDBsum
3TF2; -
; .
PDBsum
3U7X; -
; .
PDBsum
4AZA; -
; .
PDBsum
4BEA; -
; .
PDBsum
4DT6; -
; .
PDBsum
4DUM; -
; .
PDBsum
4TPW; -
; .
PDBsum
4TQB; -
; .
PDBsum
4TQC; -
; .
PDBsum
4UED; -
; .
PDBsum
5EHC; -
; .
PDBsum
5EI3; -
; .
PDBsum
5EIR; -
; .
PDBsum
5EKV; -
; .
PDBsum
5GW6; -
; .
PDBsum
5T46; -
; .
ProteinModelPortal
P06730; -
; .
SMR
P06730; -
; .
BioGrid
108292; 50
; .
DIP
DIP-22N; -
; .
IntAct
P06730; 35
; .
MINT
MINT-85626; -
; .
BindingDB
P06730; -
; .
ChEMBL
CHEMBL4848; -
; .
DrugBank
DB01649; 7-Methyl-Gpppa
; .
DrugBank
DB02716; 7-Methyl-Guanosine-5'-Triphosphate
; .
DrugBank
DB01960; 7n-Methyl-8-Hydroguanosine-5'-Diphosphate
; .
DrugBank
DB05165; LY2275796
; .
iPTMnet
P06730; -
; .
PhosphoSitePlus
P06730; -
; .
SwissPalm
P06730; -
; .
BioMuta
EIF4E; -
; .
DMDM
1352435; -
; .
OGP
P06730; -
; .
REPRODUCTION-2DPAGE
IPI00027485; -
; .
EPD
P06730; -
; .
MaxQB
P06730; -
; .
PeptideAtlas
P06730; -
; .
PRIDE
P06730; -
; .
TopDownProteomics
P06730-1; -. [P06730-1]
; .
DNASU
1977; -
; .
Ensembl
ENST00000280892; ENSP00000280892
; ENSG00000151247. [P06730-3]; .
Ensembl
ENST00000450253; ENSP00000389624
; ENSG00000151247. [P06730-1]; .
Ensembl
ENST00000505992; ENSP00000425561
; ENSG00000151247. [P06730-2]; .
GeneID
1977; -
; .
KEGG
hsa:1977; -
; .
UCSC
uc003hue.3; human. [P06730-1]
; .
CTD
1977; -
; .
DisGeNET
1977; -
; .
GeneCards
EIF4E; -
; .
H-InvDB
HIX0039231; -
; .
HGNC
HGNC:3287; EIF4E
; .
HPA
CAB004077; -
; .
HPA
CAB016316; -
; .
HPA
HPA051311; -
; .
MalaCards
EIF4E; -
; .
MIM
133440; gene
; .
MIM
615091; phenotype
; .
neXtProt
NX_P06730; -
; .
OpenTargets
ENSG00000151247; -
; .
Orphanet
106; Autism
; .
PharmGKB
PA27714; -
; .
GeneTree
ENSGT00520000055549; -
; .
HOGENOM
HOG000186751; -
; .
HOVERGEN
HBG006130; -
; .
InParanoid
P06730; -
; .
KO
K03259; -
; .
OMA
WTLWYYE; -
; .
OrthoDB
EOG091G0IVA; -
; .
PhylomeDB
P06730; -
; .
TreeFam
TF101526; -
; .
Reactome
R-HSA-1169408; ISG15 antiviral mechanism
; .
Reactome
R-HSA-156827; L13a-mediated translational silencing of Ceruloplasmin expression
; .
Reactome
R-HSA-159227; Transport of the SLBP independent Mature mRNA
; .
Reactome
R-HSA-159230; Transport of the SLBP Dependant Mature mRNA
; .
Reactome
R-HSA-159231; Transport of Mature mRNA Derived from an Intronless Transcript
; .
Reactome
R-HSA-166208; mTORC1-mediated signalling
; .
Reactome
R-HSA-429947; Deadenylation of mRNA
; .
Reactome
R-HSA-72649; Translation initiation complex formation
; .
Reactome
R-HSA-72662; Activation of the mRNA upon binding of the cap-binding complex and eIFs
; and subsequent binding to 43S; .
Reactome
R-HSA-72702; Ribosomal scanning and start codon recognition
; .
Reactome
R-HSA-72706; GTP hydrolysis and joining of the 60S ribosomal subunit
; .
SignaLink
P06730; -
; .
SIGNOR
P06730; -
; .
ChiTaRS
EIF4E; human
; .
EvolutionaryTrace
P06730; -
; .
GeneWiki
EIF4E; -
; .
GenomeRNAi
1977; -
; .
PRO
PR:P06730; -
; .
Proteomes
UP000005640; Chromosome 4
; .
Bgee
ENSG00000151247; -
; .
CleanEx
HS_EIF4E; -
; .
ExpressionAtlas
P06730; baseline and differential
; .
Genevisible
P06730; HS
; .
GO
GO:0033391; C:chromatoid body
; IEA:Ensembl; .
GO
GO:0005737; C:cytoplasm
; IDA:AgBase; .
GO
GO:0010494; C:cytoplasmic stress granule
; IDA:UniProtKB; .
GO
GO:0005829; C:cytosol
; IDA:UniProtKB; .
GO
GO:0016281; C:eukaryotic translation initiation factor 4F complex
; IDA:UniProtKB; .
GO
GO:0070062; C:extracellular exosome
; IDA:UniProtKB; .
GO
GO:0005845; C:mRNA cap binding complex
; IDA:UniProtKB; .
GO
GO:0000932; C:P-body
; IDA:HPA; .
GO
GO:0048471; C:perinuclear region of cytoplasm
; IDA:AgBase; .
GO
GO:0016442; C:RISC complex
; IDA:MGI; .
GO
GO:0019899; F:enzyme binding
; IDA:AgBase; .
GO
GO:0031370; F:eukaryotic initiation factor 4G binding
; IDA:AgBase; .
GO
GO:0070491; F:repressing transcription factor binding
; IDA:AgBase; .
GO
GO:0000340; F:RNA 7-methylguanosine cap binding
; IDA:UniProtKB; .
GO
GO:0003723; F:RNA binding
; IDA:UniProtKB; .
GO
GO:0000339; F:RNA cap binding
; TAS:ProtInc; .
GO
GO:0003743; F:translation initiation factor activity
; IDA:UniProtKB; .
GO
GO:0001662; P:behavioral fear response
; IEA:Ensembl; .
GO
GO:0071549; P:cellular response to dexamethasone stimulus
; IEA:Ensembl; .
GO
GO:0000082; P:G1/S transition of mitotic cell cycle
; IMP:UniProtKB; .
GO
GO:0030324; P:lung development
; IEA:Ensembl; .
GO
GO:0006406; P:mRNA export from nucleus
; TAS:Reactome; .
GO
GO:0045665; P:negative regulation of neuron differentiation
; IEA:Ensembl; .
GO
GO:0017148; P:negative regulation of translation
; IEA:Ensembl; .
GO
GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening
; TAS:Reactome; .
GO
GO:0045931; P:positive regulation of mitotic cell cycle
; IMP:UniProtKB; .
GO
GO:0006417; P:regulation of translation
; IDA:UniProtKB; .
GO
GO:0006405; P:RNA export from nucleus
; TAS:Reactome; .
GO
GO:0019827; P:stem cell population maintenance
; IEA:Ensembl; .
GO
GO:0006413; P:translational initiation
; TAS:Reactome; .
GO
GO:0016032; P:viral process
; IEA:UniProtKB-KW; .
Gene3D
3.30.760.10; -
; 1; .
InterPro
IPR023398; TIF_eIF4e-like
; .
InterPro
IPR001040; TIF_eIF_4E
; .
InterPro
IPR019770; TIF_eIF_4E_CS
; .
PANTHER
PTHR11960; PTHR11960
; 1; .
Pfam
PF01652; IF4E
; 1; .
SUPFAM
SSF55418; SSF55418
; 1; .
PROSITE
PS00813; IF4E
; 1; .
Gateways to other related servers
The World-2DPAGE Constellation
- Entry point to the world-wide 2-DPAGE resources.
World-2DPAGE Repository
- A public repository for gel-based proteomics data linked to protein identification published in the literature.
World-2DPAGE Portal
- A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
SWISS-2DPAGE
- The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
ExPASy
- The resources web server of the
Swiss Institute of Bioinformatics
Database constructed and maintained by
Angel Garcia
, using the
Make2D-DB II
package (
ver. 3.10.2
) from the
World-2DPAGE Constellation
of the
ExPASy web server
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